Blausen Medical
Blausen Medical

Blausen Medical

Medically accurate and informative 3D animations


Skin Damage and Aging

"Aging of the skin occurs through two primary reasons: internal factors such as inflammation and cytokines emitted from accumulated intra-cellular damage and external factors such as ultraviolet rays and pollution. The top layer of the skin is called the stratum corneum, which is a durable barrier. Underneath this we have the stratum granulosum, which functions along with epidermal lipids to form a barrier that stops water particles from escaping from the skin. Depletion of the epidermis barrier lipids and dysfunction of the stratum granulosum occur with aging and damage, which can result in water escaping the skin. Deeper in the epidermis are the melanocytes that produce melanin. Damage and aging of the skin causes melanin production to increase, leading to hyperpigmented areas on the skin. In addition to increased pigmentation, the dermoepidermal junction can begin to extend downward resulting in an age spot. The layer between the epidermis and the dermis is called the dermoepidermal junction. As we age the general structure of the dermoepidermal junction begins to flatten. The dermis is the layer of the skin that provides firmness and elasticity. In this layer, we have fibroblasts that create collagen and elastin. With aging and damage, dermal proteins are chewed up. Over time, the fibroblasts assume an inactive, non-spindle form and the number of collagen fibers in the matrix decreases. Additionally, at the base of the skin is the hypodermis with adipocytes providing plumpness to the skin. With aging and damage, the adipocytes shrink. When this occurs, the skin begins to visibly sag. The skin also contains glands connected to pores. The gland produces sebum, which travels up the hair shaft and spreads on the skin surface to help protect and provide emollience. With age sebum decreases and gland at the base of the pore shrinks while the diameter of the pore widens. The accumulated damage to the skin leads to the appearance of flakiness, fine lines and wrinkles, sagging, large pores and discolored spots. "

Duration: 02:45
Licence: CC - Attribution
Original Language: English
Published: 8/9/2019
Diseases and Conditions: Skin Problems and Treatments
Format: 3D Animation

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Skin Damage and Aging

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