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Blausen Medical
Blausen Medical

Blausen Medical

Medically accurate and informative 3D animations

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Mechanism and Inhibition of Airway Inflammation in Asthma

"Activation of allergen-specific T helper 2 (Th2) cells and ILC2 cells leads to production of IL-13, IL-5, and IL-4. IL-4 promotes B cell synthesis of IgE. IL-5 is responsible for activation of eosinophils in the tissue. IL-13 induces airway hyperresponsiveness, remodeling of airway smooth muscle, and mucus hypersecretion. An anti-IL-4/IL-13 receptor monoclonal antibody inhibits IL-4 and IL-13 mediated pathways. Therapeutic monoclonal antibodies directed against IL-5 and the IL-5 receptor block eosinophilic inflammation. An anti-IgE monoclonal antibody binds to IgE and prevents downstream cytokine production. "

Duration: 01:29
Licence: CC - Attribution
Original Language: English
Published: 8/9/2019
Diseases and Conditions: Asthma
Format: 3D Animation

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Mechanism and Inhibition of Airway Inflammation in Asthma

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