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Blausen Medical
Blausen Medical

Blausen Medical

Medically accurate and informative 3D animations

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Immune Checkpoint Immunotherapy

T cells play an important role in the immune response to cancer. Activated T cells detect, bind to, and kill tumor cells in the tumor microenvironment. Programmed Cell Death Ligand 1, or PDL1, normally helps maintain immune homeostasis (and inhibits autoimmunity). PDL1 overexpression on tumor cells and infiltrating immune cells helps tumor cells evade the immune system. PDL1 binds to its receptor, PD1, on the surface of [activated] T cells, causing inhibition of cytotoxic T cell activity. Antibodies to PDL1 and PD1 block immune checkpoint inhibition and enable the destruction of tumor cells and the control of tumor cell proliferation.

Duration: 01:08
Licence: CC - Attribution
Original Language: English
Published: 8/9/2019
Diseases and Conditions: Cancer / Tumor
Format: 3D Animation

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Immune Checkpoint Immunotherapy

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