Blausen Medical
Blausen Medical

Blausen Medical

Medically accurate and informative 3D animations


Bone Metastasis in Prostate Cancer

80% of men with castrate-resistant prostate cancer will eventually develop bone metastasis. Bone is a very rich site for the development of metastasis. Circulating prostate cancer cells enter the blood vessels and travel to the bone marrow. The tumor cells enter the microenvironment and find a conducive area to grow, much like seeds thriving in fertile soil. The cells are implanted within the bone microenvironment where they grow and secrete growth factors, proteins, and cytokines, which lead to bone turnover. The contact between tumor cells and the bone microenvironment lead to the development of bone metastases, resulting in excessive osteoblast activity that releases multiple factors, further stimulating tumor growth and the creation of bone lesions. Radionuclides mimic calcium and form complexes with bone mineral hydroxyapatite at areas of increased bone turnover such as bone metastasis. As the radionuclide decays it emits primarily high-energy alpha particles. The high linear energy transfer of alpha particles causes double strand DNA breaks in adjacent cells killing cancer cells and associated cells in osteoblast lesions while minimizing damage to healthy tissue.

Duration: 01:40
Licence: CC - Attribution
Original Language: English
Published: 8/9/2019
Diseases and Conditions: Bone Tumors / Prostate Cancer / Tumor
Format: 3D Animation

Other videos in this channel


Related Videos

Bone Metastasis in Prostate Cancer

Comments (0)

Login to add your comment
Be the first to comment!