Blausen Medical
Blausen Medical

Blausen Medical

Medically accurate and informative 3D animations



"The knee can be a site of chronic pain due to degeneration or mechanical damage to the area. The back can also experience pain due to disc herniation. The pinched nerve releases pro-inflammatory mediators such as nerve growth factor, histamine, and bradykinin. Open sodium channels allow sodium ions into the cell to aid in the depolarization of the membrane and exacerbates the inflammatory response. Peripheral ascending signals travel up the spinal cord to the brain. The brain sends signals back down the spinal cord. At a neuron level pain signals travel across the membrane. Sodium channels let sodium ions into the cell, aiding in depolarization and the creation of pain signals. NAV1.7 is a voltage-gated sodium channel. Inhibitors block the channel and cause the depolarization to stop. On another neuron synaptic vesicles release neurotransmitters. Nerve growth factor and tropomyosin receptor kinase A bind and causes depolarization and pain signaling. Monoclonal antibodies bind to nerve growth factor to prevent them from activating tropomyosin receptor kinase A. This stops the depolarization and the pain signals. Overall, the pain signals lower in intensity, leading to a lowered sensation of pain."

Duration: 02:03
Licence: CC - Attribution
Original Language: English
Published: 8/9/2019
Diseases and Conditions: Pain Management
Format: 3D Animation

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